Moist Heat Steam, Pre-Filled Syringe Sterilization, Dry Heat, and Depyrogenation Services

Prince Sterilization Services, LLC is a contract sterilization services provide that specializes in moist heat steam, Pre-Filled Syringe Sterilization, an dry heat sterilization and depyrogenation services. At Prince you will find a full suite of sterilization related support to our customers including development/feasibility, validation, and routine processing cycles. Our expert staff is ready to provide case-by-case consultation support when needed. Click here to download a brochure or continue reading below to learn more about our products and services.

• Terminal Sterilization of Drug Products
  • It is a regulatory requirement that drug products that can withstand terminal sterilization be terminally sterilized
  • Steam sterilization is the sterilization method of choice
  • We offer full product support. Development/Feasibility, Engineering, Validation, and Commercial
  • Terminal sterilization of liquids in sealed vessels (aseptically filled drug products in vials, IV bags, syringes, blow-fill-seal technologies, and others)
• Moist heat steam sterilization (pulse pre-vac, gravity, and air-over-pressure)
  • Plastic bottles and tubing
  • Glass vials
  • Stoppers and seals
  • Cell culture bags
  • Manufacturing equipment (scissors, hemostats, forceps, etc.)
  • Eco-friendly and non-toxic
• Pre-Filled Syringe Sterilization
  • Prince is equipped with state-of-the-art equipment specialized to provide sterilization of pre-filled syringes. Our experts can help establish sterilization cycles with parameters that achieve appropriate sterilization lethality without compromising stopper movement or syringe integrity. If you have a pre-filled syringe that requires sterilization, Prince is ready to support your efforts in development, engineering, validation, and commercial production.
• Dry heat sterilization
  • Heat sensitive drug products and other materials
  • Liquids in sealed containers/ampoules
  • Eco-friendly and non-toxic

• Depyrogenation
  • Glass vials
  • Manufacturing/process equipment (e.g. stainless steel)

• Water for injection (WFI) rinsing
  • Rinsing of materials such as seals, stoppers, and glass vials with WFI prior to sterilization or depyrogenation.
  • Prince Advantage™ Our process lowers bioburden, particulate and endotoxin levels as well as removing stubborn and potentially inhibitory residues.